Spectrophotometric Analysis of some Phenothiazine Neuroleptics using Chloramine-T
作者:
K. Basavaiah,
J. Manjunatha Swamy,
G. Krishnamurthy,
期刊:
Analytical Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 13
页码: 2613-2623
ISSN:0003-2719
年代: 1999
DOI:10.1080/00032719908542992
出版商: Taylor & Francis Group
关键词: Phenothiazine drugs;neuroleptics;chloramine-T;spectrophotometry;pharmaceutical preparations
数据来源: Taylor
摘要:
A sensitive and selective spectrophotometric method has been developed for the determination of six phenothiazine neuroleptics. The method is based on the interaction of the drugs with chloramine-T in sulphuric acid medium to yield a red, reddish-violet, orange or greenish-blue intermediate with maximum absorption at 500-636 nm. Beer's law is obeyed over the range 5-125 μg ml−1of the drugs. The apparent molar absorptivities were found to be in the range 1.04x103to 5.46x1031.mol−1cm−1. The investigated drugs were assayed in tablets and injections. The mean percentage recoveries were 97.65-101.75 and the relative standard deviations were found to be less than 2%.
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