Textbooks and articles that address the issues and responsibilities of a nurse manager generally focus on the role of the nurse manager in a hospital setting. While many of the principles set forth in these publications may be appropriately used by the nurse manager working in an endoscopy setting, certain characteristics of GI nursing are unique in terms of managing the delivery of patient care, managing staff, and managing self. This article describes these critical “3Ms” of nursing management and offers practical guidelines to the GI nurse manager.