Adrenergic and cholinergic receptors in isolated non-pigmented ciliary epithelial cells
作者:
PolanskyJon R.,
ZlockDouglas,
BrasierAnne,
BloomErnest,
期刊:
Current Eye Research
(Taylor Available online 1985)
卷期:
Volume 4,
issue 4
页码: 517-522
ISSN:0271-3683
年代: 1985
DOI:10.3109/02713688509025168
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Methods were developed to isolate non-pigmented ciliary epithelium from bovine eyes (BCBE) free from other cell types in the ciliary process. Once background binding due to pigment was minimized, it was possible to assay specific beta adrenergic receptors in these preparations. The BCBE beta adrenergic receptors showed appropriate stereospecificity and an order of binding affinities compatible with a beta2 adrenergic selectivity. Interestingly, specific high affinity muscarinic cholinergic receptors were detected in both BCBE and primate non-pigmented ciliary epithelium. These muscarinic receptors showed an appropriate affinity and selectivity for agonists and antagonists.Further evaluations of the receptors and responses of non-pigmented ciliary epithelial cells may prove useful in understanding the effects of adrenergic and cholinergic agents on aqueous humor inflow.
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