The Effect of Portal Diversion on the Early Stages of Liver Carcinogenesis in the Rat
作者:
Lorne E. Rotstein,
Leonard Makowka,
George Lee,
Emmanuel Farber,
期刊:
Hepatology
(WILEY Available online 1982)
卷期:
Volume 2,
issue 1
页码: 67-71
ISSN:0270-9139
年代: 1982
DOI:10.1002/hep.1840020111
出版商: W.B. Saunders
数据来源: WILEY
摘要:
AbstractThe effect of portal diversion by ameroid constriction was studied in the carcinogenic process in the rat after initiation of foci by diethylnitrosamine and after the establishment of putative preneoplastic nodules. Portal diversion or portal diversion plus partial hepatectomy did not act to promote or select for the development of nodules. Furthermore, portal diversion did not alter the natural history of established nodules. These results suggest that vascular factors are not important at these early stages of the carcinogenic process in the rat liver.
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