Distribution of ORM1, C6, C7 and APO C-ll Allele Frequencies in Populations from Mainland Italy and Sardinia
作者:
R. Scacchi,
R.M. Corbo,
G. Cossu,
L. Mureddu,
G. Mulas,
R. Pascone,
期刊:
Human Heredity
(Karger Available online 1992)
卷期:
Volume 42,
issue 5
页码: 309-315
ISSN:0001-5652
年代: 1992
DOI:10.1159/000154088
出版商: S. Karger AG
关键词: ORM1 C6;C7 APO C-II;Polymorphism;Isoelectric focusing;Immunoblotting;Italy;Sardinia
数据来源: Karger
摘要:
The genetic variation of the human plasma proteins ORM1, C6, C7 and APO C-II was investigated by isoelectric focusing followed by immunoblotting in populations from mainland Italy and Sardinia. The frequencies of ORM1*1 were 0.621 and 0.564, while those of C6*A were 0.657 and 0.706 on mainland Italy and in Sardinia, respectively. In the Roman sample, 8 het-erozygotes with C6 variant alleles were encountered, while none were observed in Sardinians. For C7 and APO C-II a number of heterozygotes with the rare alleles C7*2 and APO C-II*2 were found, but their frequency did not reach polymorphic levels in either population. The two populations showed a significant difference in the gene frequencies distribution for ORM1.
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