Enoxacin: Polarographic Behaviour and Its Determination in Pharmaceutical Forms
作者:
J.A. Squella,
A. Alvarez-Lueje,
J.C. Sturm,
L.J. Núñez-Vergara,
期刊:
Analytical Letters
(Taylor Available online 1993)
卷期:
Volume 26,
issue 9
页码: 1943-1957
ISSN:0003-2719
年代: 1993
DOI:10.1080/00032719308017442
出版商: Taylor & Francis Group
关键词: dp polarography;enoxacin;drug analysis
数据来源: Taylor
摘要:
A differential pulse polarographic method for the identification and quantitative determination of enoxacin is described. The method is based on the electrochemical reduction of the drug at the dropping mercury electrode. It gives a well-developed polarographic response with a half-wave potential of -990 mV vs. SCE in 0.1 M HCl. The electroactive specie exhibits a diffusion-controlled polarographic wave and its limiting current shows a linear dependence with the enoxacin concentration in the range between 5.10−4mM and 1 mM. This characteristic is applied for determination of enoxacin in commercial tablets. The recovery study shows a good accuracy and precision for the developed assay (average of 101.1% and standard deviation of 1.99). Furthermore, a comparative UV spectrophotometric assay also is developed.
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