Antibody‐Dependent Cellular Cytotoxicity and Natural Killer Activity Against HTLV‐1 Infected Cells
作者:
Taiji Kunitomi,
Hirotoshi Takigawa,
Makio Sugita,
Shin Nouno,
Masayuki Suemune,
Masakatsu Inoue,
Nobuyuki Kodani,
Megumi Oda,
Masanori Ikeda,
期刊:
Pediatrics International
(WILEY Available online 1990)
卷期:
Volume 32,
issue 1
页码: 16-19
ISSN:1328-8067
年代: 1990
DOI:10.1111/j.1442-200X.1990.tb00778.x
出版商: Blackwell Publishing Ltd
关键词: ADCC;NK;HTLV‐1;Vertical transmision
数据来源: WILEY
摘要:
Antibody‐dependent cellular cytotoxicity (ADCC) and natural killer (NK) ativity were examined using MT‐2 cells persistently infected by HTLV‐1 as target cells, and mononuclear cells as effector cells, from helathy one‐week‐old newborn babies, infants, children and adults. More than 10% of ADCC was observed in 17 newborn babies out of 22 (77.3%) and in all 67 healthy one‐month‐old babies to adults, by adding serum from anti‐HTLV‐1 positive carriers. When anti‐HTLV‐1 negative serum was added, less than 10% of ADCC was observed. If infants without anti‐HTLV‐1 antibodies were breast‐fed they had the possibility of HTLV‐1 vertical transmission. There was no significant decrease in NK activity between 90 healthy newborn babies, infants, children, or adults. These results suggest that ADCC and NK activity protect against the transmission o
点击下载:
PDF
(210KB)
返 回