Enhanced AP‐1 binding in brain induced by D1 and D2 agonists in methamphetamine‐sensitized rats
作者:
Takeshi Ishihara,
Kazufumi Akiyama,
Kenichi Kashihara,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 17
页码: 3913-3917
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: AP-1 binding activities;Behavioral sensitization;Dopamine D1 and D2 receptors;Methamphetamine;Quinpirole;SKF-38393
数据来源: OVID
摘要:
THE activator protein-1 (AP-1) binding activities induced by a separate challenge with SKF38393 and quinpirole after 1 weeks’ abstinence from chronic methamphetamine (4 mg/kg/day, 14 days) were increased significantly in the striatum, nucleus accumbens and cingulate cortex compared with the saline-treated controls. Quinpirole-, but not SKF38393-induced AP-1 binding activities were still significantly higher after a 4-week abstinence period in the chronic methamphetamine group than in the chronic saline control group. Downward sniffing, which occurred following a quinpirole-challenge, was significantly intensified after both a 1 and 4 weeks’ abstinence from chronic methamphetamine. These results indicate that chronic administration of methamphetamine induces alterations of the interactions of dopamine D1 and D2 receptors which are reflected as enhanced AP-1 binding activities.
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