SUMMARYThe antifungal effect of an aqueous extract of garlic was tested against 18 strains ofCryptococcus neoformans.Nine strains were clinical isolates, eight were laboratory-induced pseudohyphal variants, and one was an ultraviolet-radiation-induced, nonencapsulated mutant. Saturated-disk sensitivity tests showed average zones of inhibition of 37.9 mm. Quantitative disk tests (20μl garlic extract per disk) revealed average zones of inhibition of 17.8 mm on Sabouraud-dextrose agar and 17.3 mm on modified Czapek-Dox agar. Tube dilution tests of twoC. neoformansstrains showed that garlic extract concentrations≥1: 512 were fungicidal. The results of this study reveal that low concentrations of aqueous garlic extract are both inhibitory and lethal to numerous strains ofC. neoformans.