The antiherpesvirus activity and cytotoxicity of sangivamycin
作者:
O'brienWilliam J.,
TaylorJerry L.,
O'malleyThomas P.,
RitchPaul S.,
期刊:
Current Eye Research
(Taylor Available online 1987)
卷期:
Volume 6,
issue 1
页码: 255-257
ISSN:0271-3683
年代: 1987
DOI:10.3109/02713688709020100
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Sangivamycin, 4-amino-5-carboxamido-7-(β-D-ribo-furanosyl)-pyrrolo[2,3-d]-pyrimidine is a structural analog of adenosine belonging to a group of nucleosides classified as pyrrolopyrimidines. Sangivamycin, an adenosine deaminase resistant analog, was found to inhibit the replication of three strains of herpes simplex virus type 1 (HSV-1) by 50% (ED50) at a concentration approximately equal to the concentration which inhibits cell growth by 50% (LD50). Both Vero cells and rabbit corneal stromal cells in exponential growth were about 10-fold more sensitive to the drug than quiescent cells. The selectivity indices of sangivamycin indicated that the drug was not a highly selective antiviral agent and, therefore, would offer no advantage over drugs currently available for the treatment of herpetic keratitis.
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