Cardiovascular reactivity and design in rats with experimental “neurogenic hypertension”
作者:
John Vann Jones,
Margareta Hallbäck,
期刊:
Acta Physiologica Scandinavica
(WILEY Available online 1978)
卷期:
Volume 102,
issue 1
页码: 41-49
ISSN:0001-6772
年代: 1978
DOI:10.1111/j.1748-1716.1978.tb06044.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractThe arterial baroreceptors were denervated in 20 normotensive Wistar rats. 2 1/2 months after the operation their cardiovascular responses to “mental stress” were compared to those of matched control rats (NCR). At the time of investigation the blood pressure of the baroreceptor denervated rats (BDR) was increased some 15 per cent above that of the control group. There was, however, no difference in response to “mental stress” between groups, if anything the BDR responded with less pronounced tachycardia. Two months subsequent to the stress‐test the mean blood pressure of the BDR was still significantly above normal levels, but the BDR did not exhibit structural cardiovascular adaptation, which has been documented in most types of stable hypertension as a response to the increased mean blood pressure. The results imply that hypertension induced by baroreceptor denervation is not of a stable and persistent type in which case structural changes in the cardiovascular system would have developed within the observation period (approximately 4 months). Emotional stimuli, however, do not seem to contribute to periodic blood pressure increases at the time of measurement, as earlier
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