Formation of free radicals during phacoemulsification
作者:
HolstAnnsofi,
RolfsenWenche,
SvenssonBengt,
ÖllingerKarin,
LundgrenBjÖRn,
期刊:
Current Eye Research
(Taylor Available online 1993)
卷期:
Volume 12,
issue 4
页码: 359-365
ISSN:0271-3683
年代: 1993
DOI:10.3109/02713689308999460
出版商: Taylor&Francis
数据来源: Taylor
摘要:
During phacoemulsification cavitation bubbles are formed. These bubbles are believed to be one source of damage to corneal endothelium seen after phacoemulsification. Free radicals are induced whenever cavitation bubbles implode. The aim of this study was to confirm the initiation of free radicals by phacoemulsification and to correlate the power of ultrasound in the phacoemulsification process to the amount of free radicals formed, using bothin vitroandin vivotechniques.The formation of free radicals was determined by adding luminol to a buffer and measuring the chemoluminescenscein vitroand in rabbit eyes (Lumacounter™2080 or a single-photon-counting apparatus) during phacoemulsification. The data obtained show that free radicals are formed during phacoemulsification and that the amount of free radicals correlates with the power of ultrasound. Furthermore, the radical formation could be inhibited by the radical scavengers SOD, Healon®and Healon®GV. These results were achieved bothin vitroin the test tube andin vivoin rabbit eyes. By showing that the addition of SOD to the irrigation buffer during phacoemulsification decreases the corneal endothelial cell damage, we show that free radicals could have a role in postoperative complications seen clinically.
点击下载:
PDF (816KB)
返 回