The behavior of many dispersed two‐phase systems, such as bubbly flows and droplet mists, are strongly affected by interfacial effects. A statistical approach is presented here which may be used to model the global behavior of such geometrically complex systems. This approach describes the interfaces as a distribution of differential surface patches, each having two local, independent principal curvatures. Statistically‐averaged (mean‐field) physics describing the appropriate phenomena are formulated for the individual patches. These physics can include the volume‐fraction effects of the dispersed phase, as well as flow conditions and interfacial phenomena. The resulting local patch dynamics are then used in a distributional analysis to predict the ensemble behavior and evolution of the dispersed system. Application of this approach to diffusive coarsening in solid‐liquid systems will be described briefly, along with suggestions of applications to other two‐phase systems of interest.