Significance of Homologous Donor Blood to the Toxic Reaction in Dogs Undergoing Extracorporeal Hemodialysis
作者:
Frank Maher,
Lee Watkins,
James Broadbent,
Jesse Bollman,
期刊:
Circulation Research
(OVID Available online 1958)
卷期:
Volume 6,
issue 1
页码: 47-54
ISSN:0009-7330
年代: 1958
出版商: OVID
数据来源: OVID
摘要:
Application of hemodialysis to dogs has been complicated by an acute reaction consisting of hypotension, bradycardia and respiratory depression followed by instability and a mortality rate of about 30 per cent. This reaction appears to be a response to homologous blood used to fill the dialyzers. Sensitization occurs in survivors, and accentuated reactions with marked hemolysis are noted on subsequent challenge. Cross matching the donor and recipient bloods has not permitted an adequate determination of compatibility under the conditions of hemodialysis. Satisfactory hemodialysis may be accomplished in dogs by using autogenous blood or blood substitutes to fill the dialyzers.
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