Effects of Dietary Sodium and Magnesium on Cyclosporin A-Induced Hypertension and Nephrotoxicity in Spontaneously Hypertensive Rats
作者:
Eero M.A. Mervaala,
Anna-Kaisa Pere,
Leena Lindgren,
Juha Laakso,
Terttu-Liisa Teravainen,
Kirsi Karjala,
Heikki Vapaatalo,
Juhani Ahonen,
Heikki Karppanen,
期刊:
Hypertension
(OVID Available online 1997)
卷期:
Volume 29,
issue 3
页码: 822-827
ISSN:0194-911X
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
Arterial hypertension, nephrotoxicity, and magnesium loss are common side effects of the immunosuppressive agent cyclosporin A (CsA). In the present study, the effects of dietary sodium and magnesium on CsA toxicity were examined in spontaneously hypertensive rats. A 6-week treatment with CsA during a moderately low-sodium diet (Na 0.3%, Mg 0.2% of the dry weight of the chow) raised blood pressure only slightly, without evidence of nephrotoxicity. By contrast, CsA during a high-sodium diet (Na 2.6%) produced a pronounced rise in blood pressure as well as marked nephrotoxicity, comprising decreased creatinine clearance, increased levels of serum creatinine and urea, and increased urinary protein excretion. During the high-sodium diet, CsA decreased myocardial and bone magnesium concentration and increased myocardial and renal calcium concentration. Magnesium supplementation (Mg 0.6%) protected against the CsA-induced hypertension and nephrotoxicity during the high-sodium diet. Magnesium supplementation also completely prevented the CsA-induced myocardial magnesium depletion and calcium accumulation in the heart and kidney during the high-sodium diet. Our findings indicate a detrimental interaction between increased sodium intake and CsA treatment and a marked protection by concomitant oral magnesium supplementation. (Hypertension. 1997;29:822-827.)
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