Brain irradiation: Effects on regional MAO and COMT activity in the brain of the squirrel monkey and on the incorporation of [14C]tyrosine into catecholamines
作者:
LouiseL. Hsu,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1984)
卷期:
Volume 14,
issue 5-6
页码: 749-758
ISSN:0098-4108
年代: 1984
DOI:10.1080/15287398409530623
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The effects of brain irradiation on the enzyme activity of monoamine oxidase (MAO) and catecholamine O‐methyltransferase (COMT), as well as on the rate of incorporation of [14C]tyrosine into catecholamines (CAs), were examined in brain regions of the squirrel monkey (Saimiri sciureus). Results indicated that proton irradiation of the striate visual cortex at either 10,000 or 20,000 rad drastically affected the MAO activity, moderately affected the COMT activity, and significantly altered the incorporation of [14C]tyrosine into CAs in several brain regions.
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