HEMOLYSIS OF HUMAN ERYTHROCYTES BY ACTIVATED OXYGEN SPECIES
作者:
A. M. Michelson,
P. Durosay,
期刊:
Photochemistry and Photobiology
(WILEY Available online 1977)
卷期:
Volume 25,
issue 1
页码: 55-63
ISSN:0031-8655
年代: 1977
DOI:10.1111/j.1751-1097.1977.tb07424.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract—The hemolysis of human erythrocytes by irradiation at 254 nm has been studied. Neither superoxide radicals nor singlet oxygen play a significant rôle and it is likely that the major species involved are hydroxyl radicals and, indirectly, carbonate anion or formate radicals. Similarly, when erythrocytes are treated with a system commonly used as source of superoxide radicals (photoreduction of riboflavin) it has been demonstrated that O‐2does not participate in lysis, but that singlet oxygen (possibly with hydroxyl radicals) is a major oxygen species involved in destruction of the cell memb
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