Effects of Aging on the Immune System
作者:
WeigleWilliam O.,
期刊:
Hospital Practice
(Taylor Available online 1989)
卷期:
Volume 24,
issue 12
页码: 112-119
ISSN:2154-8331
年代: 1989
DOI:10.1080/21548331.1989.11703827
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Most cell-mediated and humoral immune responses decline with advancing age. Both the T- and B-cell compartments show deficiencies in activation, transit through the cell cycle, and subsequent differentiation. The T-cell compartment, notably the CD4 subset, which includes helper cells, is most affected by thymic involution. The mucosal immune system is relatively unaffected.
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