Serum Fluoxetine and Norfluoxetine Concentrations and Antidepressant Response
作者:
Michael Kelly,
Paul Perry,
Sheldon Holstad,
Michael Garvey,
期刊:
Therapeutic Drug Monitoring
(OVID Available online 1989)
卷期:
Volume 11,
issue 2
页码: 165-170
ISSN:0163-4356
年代: 1989
出版商: OVID
关键词: Antidepressant response;Fluoxetine;Norfluoxetine.
数据来源: OVID
摘要:
A high-performance liquid chromatography assay for fluoxetine and its major metabolite, norfluoxetine, was established. Serum concentrations of the two were measured in 13 depressed outpatients following a 6-week trial of the drug. No significant correlations were obvious between clinical improvement as measured by the Hamilton Rating Scale for Depression and the Clinical Global Impression scores and the serum concentrations of fluoxetine and its major metabolite, norfluoxetine, according to these initial pilot data.
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