The influence of neutron (ø = 107n/cm2.s) irradiation on the hardness and fracture strength of the amorphous alloy Ni40Fe6Co20Cr12Mo6B16is studied at room temperature. There is little influence up to the fluence of 2 × 1012n/cm2, however, hardening is observed at higher fluences. While the hardness continues to increase from the fluence 2 × 1012n/cm2to 4.3 × 1013n/cm2, the fracture strength attains a peak value at fluence of ≃1013n/cm2, however, is drastically reduced at higher fluences. The results are discussed in terms of radiation induced defects and consequent formation of clusters like (Fe, Ni)3B