Fragile X expression studied by clonal analysis and somatic cell hybridization
作者:
E.M. Bryant,
G.M. Martin,
H. Hoehn,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1983)
卷期:
Volume 35,
issue 3
页码: 223-225
ISSN:1424-8581
年代: 1983
DOI:10.1159/000131870
出版商: S. Karger AG
数据来源: Karger
摘要:
The expression of the fragile site on the X chromosome was examined in euploid somatic cell hybrids to determine if a normal genome could complement the abnormal genome and suppress fragile X expression. Fibroblasts from the patient showed the fragile X in 8% to 12% of cells, and fibroblasts from the normal individual showed no fragile X expression. Six fibroblast clones from the patient showed a variable frequency of fragile X expression (from 6.6% to 12%), suggesting that the fragile X is not expressed in a clonal fashion. Three clones from the normal individual did not show the fragile X. Four hybrid clones showed the fragile X in 5.6%, 4.0%, 7.0%, and 4.0% of cells, respectively, indicating that fragile X expression is not completely suppressed by the normal genome.
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