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Beef tallow, but not corn bran or soybean polysaccharide, reduces large intestinal and fecal bile acid concentrations in rats

 

作者: GallaherDanielD.,   ChenChia‐Ling,  

 

期刊: Nutrition and Cancer  (Taylor Available online 1995)
卷期: Volume 23, issue 1  

页码: 63-75

 

ISSN:0163-5581

 

年代: 1995

 

DOI:10.1080/01635589509514362

 

出版商: Taylor&Francis Group

 

数据来源: Taylor

 

摘要:

AbstractDiets high in fat and low in dietary fiber have been associated with a higher incidence of colon cancer, possibly by increasing bile acid concentration in the colon. Therefore changes in bile acid metabolism due to beef tallow, corn bran (CB), and soy polysaccharide (SP) feeding were studied. Rats were fed one of four diets for six weeks: 5% beef tallow fiber‐free (LF), 20% beef tallow fiber‐free (HF), 20% beef tallow with CB (HFCB), and 20% beef tallow with SP (HFSP). HF increased fecal output compared with LF, and HFCB and HFSP increased fecal output compared with HF. HF reduced fecal bile acid concentration by two‐thirds compared with LF, although daily bile acid excretion was similar. There was a tendency toward a smaller bile acid quantity in the small intestine with HF than with LF. Neither fiber altered total fecal bile acid concentration or small intestinal bile acid quantity compared with HF. However, 7α‐dehydroxy‐lase activity in the colon was lower with HFSP than with HFCB. Increasing dietary beef tallow from 5% to 20% in animals fed a fiber‐free diet greatly reduced the concentration of bile acids in the large intestine and feces, an effect associated with a reduced risk of colon cancer.

 

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