Evidence of infection with organisms producing Shiga‐like toxins in household contacts of children with the hemolytic uremic syndrome
作者:
EDUARDO LOPEZ,
MARIO DIAZ,
SUSANA DEVOTO,
SAUL GRINSTEIN,
MABEL WOLOJ,
BARBARA MURRAY,
ETELVINA RUBEGLIO,
FERNANDO MENDILAHARZU,
MARISA TURCO,
MIRIAM VASQUEZ,
LARRY PICKERING,
THOMAS CLEARY,
期刊:
The Pediatric Infectious Disease Journal
(OVID Available online 1991)
卷期:
Volume 10,
issue 1
页码: 20-24
ISSN:0891-3668
年代: 1991
出版商: OVID
关键词: Shiga-like toxin;household contacts;hemolytic uremic syndrome
数据来源: OVID
摘要:
We conducted a prospective study in 87 household contacts of 51 children with hemolytic uremic syndrome to determine the frequency of infection with Shiga-like toxin-producing bacteria. Gastrointestinal tract symptoms occurred in only 1 of 87 contacts. Free fecal toxin was detected in 25 of 64 (39%) of the household members. Neutralization with specific antisera to Shiga-like toxins I and II (SLT-I, SLT-II) revealed that in 6 of these household contacts only SLT-I was present in stool, in 10 only SLT-II was present and in 9 both toxins were found. Thirty-three percent of the hemolytic uremic syndrome families in which 2 or more members were studied had more than 1 household member with free fecal toxin in stool. None of the household contacts was found to haveE. coli0157:H7 in feces. Serum samples were available in 77 household contacts; 75% (58 of 77) had serum neutralizing liters of ≥ 1:4 to 1 or both toxins. In those contacts for whom paired sera were available, seroconversion was found in 10 of 24 (42%). These data show that household contacts of children with hemolytic uremic syndrome are commonly colonized with Shiga-like toxin-producingE. coliand seroconversion to Shiga-like toxins occurs frequently in family members of children with hemolytic uremic syndrome.
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