Enantiomeric Recognition by Molecularly Imprinted Polymers Using Hydrophobic Interactions
作者:
Cong Yu,
Olof Ramström,
Klaus Mosbach*,
期刊:
Analytical Letters
(Taylor Available online 1997)
卷期:
Volume 30,
issue 12
页码: 2123-2140
ISSN:0003-2719
年代: 1997
DOI:10.1080/00032719708001728
出版商: Taylor & Francis Group
关键词: molecular imprinting;hydrophobic interactions;enantiomeric recognition;aqueous media;polymer
数据来源: Taylor
摘要:
Molecularly imprinted polymers prepared using acrylamide as the hydrogen bonding functional monomer exhibited good enantiomeric recognition properties in aqueous solutions. Our results indicate that the recognition improved with increased mobile phase water percentage and ionic strength, and was also very much pH dependent upon the ionisation properties of the sample molecules. The results can be interpreted in terms of specific hydrophobic interactions between the enantiomeric species and the recognition sites of imprinted polymers. A study of substrate selectivity showed differences between a pure organic system and a water/organic system as the mobile phases. The hydrophobicity of the test compounds was found to be an important parameter in determining the selectivity.
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