Effects of GR 68755 ond-amphetamine‐induced changes in mood, cognitive performance, appetite, food preference, and caloric and macronutrient intake in humans
作者:
B. Johnson,
D. Oldman,
E. Goodall,
Y. Chen,
P. Cowen,
期刊:
Behavioural Pharmacology
(OVID Available online 1996)
卷期:
Volume 7,
issue 3
页码: 216-227
ISSN:0955-8810
年代: 1996
出版商: OVID
关键词: Caloric intake - Cognitive performance -d-amphetamine - Human - Macronutrient intake - 5-HT3antagonist - Mood
数据来源: OVID
摘要:
Pre-clinical studies have suggested that 5-HT3antagonists such as GR 68755 oppose mesocorticolimbic dopamine release, which may mediate the important effects ofd-amphetamine on positive subjective mood, anorexia, and performance. Twenty-six healthy male volunteers received each of the following treatments in a double-blind, randomized, cross-over design separated by a period of four to seven days: (a)d-amphetamine (20 mg orally); (b) placebo; (c) GR 68755 (2 mg orally); and (d) GR 68755 plusd-amphetamine. Subjects completed subjective measures of mood, hunger, and satiety. Caloric and macronutrient intake were measured using a test meal. Performance and attention were assessed using standardized computerized tasks. GR 68755 enhanced accuracy on the computerized attention task but failed to reverse significantly any of the effects ofd-amphetamine. These results suggest that at these doses GR 68755 pre-treatment does not significantly reduce the effects ofd-amphetamine.
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