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Molecular characterization of human X/Y translocations suggests their aetiology through aberrant exchange between homologous sequences on Xp and Yq

 

作者: A. Ballabio,   R. Carrozzo,   A. Gil,   B. Gillard,   N. Affara,   M. A. Fferguson‐Smith,   N. Fraser,   I. Craig,   M. Rocchi,   G. Romeo,   G. Andria,  

 

期刊: Annals of Human Genetics  （WILEY Available online 1989）
卷期: Volume 53, issue 1  

页码: 9-14

 

ISSN:0003-4800

 

年代: 1989

 

DOI:10.1111/j.1469-1809.1989.tb01117.x

 

出版商: Blackwell Publishing Ltd

 

数据来源: WILEY

 

摘要:

SummarySeveral DNA sequences from two homologous regions, localized on the distal part of the human X chromosome short arm and on the long arm of the Y chromosome, have been hybridized to DNAs from seven human‐rodent hybrids containing human X; Y translocation chromosomes. Molecular characterization of the translocated chromosomes has revealed, in all but one case, transfer of the Y cluster of sequences and complete deletion of the corresponding X‐chromosomal sequences. The possible role of X/Y homology in the aetiology of X; Y translocations is propo

 

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