Adipocyte j8‐Adrenoceptor Sensitivity Influences Plasma Lipid Levels
作者:
Peter Arner,
Hans Wahrenberg,
Fredrik Lonnqvist,
Bo Angelin,
期刊:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
(OVID Available online 1993)
卷期:
Volume 13,
issue 7
页码: 967-972
ISSN:1049-8834
年代: 1993
出版商: OVID
关键词: adipocytes;ftadrenergic receptors;plasma lipids
数据来源: OVID
摘要:
Catecholamine stimulation of lipolysis through adipocyte ftadrenoceptors is of major importance for the regulation of lipid mobilization from adipose tissue. The influence of adipocyte 0-receptor sensitivity as assessed by an isoprenaline bioassay on circulating lipid levels was investigated in 46 healthy and drug-free subjects. /9-Receptor sensitivity was inversely related to total plasma triglycerides (r=−.62), very low density lipoprotein cholesterol (VLDL-C) (r=−.56), VLDL triglycerides (r=−.52), and apolipoprotein B (r=—.41). These relationships remained significant after adjustment for age, sex, body mass index, waist/hip ratio, fat cell volume, and circulating levels of insulin, noradrenaline, and adrenaline. ftReceptor sensitivity accounted for 40% of the variance in total plasma triglycerides. ftReceptor subtype sensitivity and binding capacity were also determined in fat cells using terbutaline (ft) and dobutamine (ft) bioassays and radioligand binding. Multiple regression analysis revealed that terbutaline sensitivity correlated inversely with total plasma triglycerides, apolipoprotein B, VLDL-C, and VLDL triglycerides (partial r from —.56 to —.42), but there was no correlation between dobutamine sensitivity and blood lipids (partial r from.05 to .18) or between receptor binding and blood lipids (partial r from .01 to 28). Thus, the llpolytic β-receptor sensitivity in fat cells appears to play a hitherto-unrecognized role for lipoprotein metabolism, in particular that of VLDL. This relationship is receptor-subtype specific, particularly involving ft-receptors, and seems to be localized to a postreceptor step in lipolysis regulation. Low sensitivity may be of importance for the development of hypertriglyceridetnia.
点击下载:
PDF
(447KB)
返 回