Lipid Peroxidation and Free Radical Scavengers in Alzheimer’s Disease
作者:
C. Jeandel,
M.B. Nicolas,
F. Dubois,
F. Nabet-Belleville,
F. Penin,
G. Cuny,
期刊:
Gerontology
(Karger Available online 1989)
卷期:
Volume 35,
issue 5-6
页码: 275-282
ISSN:0304-324X
年代: 1989
DOI:10.1159/000213037
出版商: S. Karger AG
关键词: in vivo;Free radicals;Alzheimer’s disease;Lipid peroxidation
数据来源: Karger
摘要:
Lipid peroxidation products and defenses against free radical damage were determined in serum of 55 patients with senile dementia of the Alzheimer type (SDAT) and compared with values in 24 age-matched healthy control subjects. The following parameters were evaluated: lipid-conjugated dienes and trienes, malondialdehyde, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in erythrocytes, vitamins E, C and A, zinc, selenium and copper, ceruloplasmin, transferrin and albumin. The results showed a statistically significant decrease in the levels of GSH-Px, vitamins E, C and A, zinc, transferrin and albumin in the SDAT group. On the other hand, most of the deficiencies concern the malnourished subgroup of the SDAT population (SOD, GSH-Px, vitamins E and C, selenium, zinc, transferrin and albumin). Such an alteration of free radical scavengers in the malnourished subgroup of the SDAT population could combine the radical and nutritional hypothesis advanced by some authors.
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