Glucose fatty acid interactions and the regulation of glucose disposal
作者:
Philip J. Randle,
David A. Priestman,
Sharad C. Mistry,
Antony Halsall,
期刊:
Journal of Cellular Biochemistry
(WILEY Available online 1994)
卷期:
Volume 55,
issue S1994A
页码: 1-11
ISSN:0730-2312
年代: 1994
DOI:10.1002/jcb.240550002
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: pyruvate dehydrogenase complex;pyruvate dehydrogenase kinase;pyruvate dehydrogenase phosphatase;hexokinase;phosphofructokinase 1;phosphofructokinase 2;glucose 6‐phosphatase;Cori cycle starvation;diabetes
数据来源: WILEY
摘要:
AbstractGlucose is essential for the energy metabolism of some cells and conservation of glucose is obligatory for survival during starvation. The principal site of this glucose conservation is the mitochondrial pyruvate dehydrogenase (PDH) complex, which is regulated by reversible phosphorylation (phosphorylation is inactivating). In cells in which glucose oxidation is switched off during starvation, fatty acids are used as fuel, and acetyl CoA and NADH formed by β‐oxidation promote phosphorylation of PDH complex by activation of PDH kinase. A longer‐term mechanism further increases PDH kinase activity in response to cAMP and products of β‐oxidation of fatty acids. Coordinated inhibition of glycolytic flux mediated by effects of citrate on PFK1 and PFK2 in muscles and liver results in an associated inhibition of glucose uptake. Similar mechanisms lead to impaired glucose oxidation in diabetes. © 1994 Wiley
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