SUMMARYStudies have been carried out onPleurotus tuber-regium, a tropical sclerotial basidiomycete obtained in Nigeria. Both the Sclerotium and the fruit bodies are edible. The economic importance to the Nigerian people, particularly in traditional medicine, is discussed.When kept in a warm, humid atmosphere, the Sclerotium readily produced fruit bodies which matured within seven da. Minimum temperature for mycelial growth was around 15, optimum 35, and maximum around 40 C. The fungus utilized as carbon sources a number of carbohydrates including fructose, mannose, xylose, glucose, cellobiose, maltose, dextrin, starch, cellulose, mannitol and sorbitol.