In vivoLocalisation of Radiolabeled Monoclonal Antibody in Human Gliomas
作者:
BehnkeJ.,
P.J.,
BucheggerF.,
CarrelS.,
DelaloyeB.,
De TriboletN.,
期刊:
British Journal of Neurosurgery
(Taylor Available online 1988)
卷期:
Volume 2,
issue 2
页码: 193-197
ISSN:0268-8697
年代: 1988
DOI:10.3109/02688698808992669
出版商: Taylor&Francis
关键词: In vivo localization;monoclonal antibody;human glioma
数据来源: Taylor
摘要:
F(ab')2-fragments of the anti-melanoma monoclonal antibody Mel-14 were labelled with123I for external scanning and withl25I for tissue measurement of radioactivity and injected intravenously into patients scheduled for surgical resection of a glioma. The paired-label study was performed by injecting simultaneously131I-labelled control (F(ab')2-fragments. The patients were scanned by computerised tomoscintigraphy. After surgery, the activities of125I andl3I were counted in tumour and normal tissues. The results indicate that there was a low but definite uptake of the antibody in the tumour due to its specificity. The external detection was difficult because of accumulation of antibody fragments in the skull.
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