Monoamine oxidase and succinate dehydrogenase inhibitory properties of substituted 1,3,4‐oxadiazole‐2‐thiones
作者:
Namita Soni,
J. P. Barthwal,
A. K. Saxena,
K. P. Bhargava,
S. S. Parmar,
期刊:
Journal of Heterocyclic Chemistry
(WILEY Available online 1982)
卷期:
Volume 19,
issue 1
页码: 29-32
ISSN:0022-152X
年代: 1982
DOI:10.1002/jhet.5570190103
出版商: Wiley‐Blackwell
数据来源: WILEY
摘要:
AbstractFifteen new 3‐arylaminomethyl‐5‐(2‐hydroxy‐3,5‐dibromophenyl)‐1,3,4‐oxadiazole‐2‐thiones were synthesized and characterized by their sharp melting points, elemental analyses and ir spectra. These substituted oxadiazolylthiones were evaluated for their enzyme inhibitory activity. All compounds inhibitedin vitromonoamine oxidase and succinate dehydrogenase activity of rat brain homogenates. The degree of monoamine oxidase inhibition ranged from 59‐93% at a final concentration of 1 × 10−4Mwhereas the inhibition of succinate dehydrogenase was 49‐100% at a final
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