Effects of nitric oxide modulation on tumour blood flow and microvascular permeability in C6 glioma
作者:
Gopal Swaroop,
George Malcolm,
Paul Kelly,
Isobel Ritchie,
Ian Whittle,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 11
页码: 2577-2581
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Blood flow;Brain tumour;C6 Glioma;Capillary permeability;Nitric oxide;Nitric oxide synthase
数据来源: OVID
摘要:
C6 glioma strongly express nitric oxide synthase. Rats bearing C6 tumours were pre-treated with i.v. Ng-nitro-L-arginine methyl ester (L-NAME), 3-morpholinosydnonimine (SIN-1) or saline before local cerebral blood flow (LCBF) or tumour capillary permeability (TCP) was measured by the [14C]iodoantipyrine autoradiographic or [14C]α-amino-isobutyric acid techniques. L-NAME and SIN-1 caused significant TBF alterations (−44% and +136%, respectively) with less marked (−15% and +33%) alterations in normal brain. Calculated cerebrovascular resistance changes within tumour were indeed selective. Baseline TCP was increased compared with normal brain (20-fold). L-NAME and SIN-1 administration did not alter TCP. These effects have significant implications for human malignant glioma management. Selective i.v. manipulation of LCBF, without significant changes in TCP, could increase the efficacy of chemotherapy, radiotherapy or provide better peritumoural oedema control.
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