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The influence of strain, maternal age, and method of maturation on mouse oocyte aneuplo...
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The influence of strain, maternal age, and method of maturation on mouse oocyte aneuploidy
作者:
M.S. Golbus,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1981)
卷期:
Volume 31,
issue 2
页码: 84-90
ISSN:1424-8581
年代: 1981
DOI:10.1159/000131629
出版商: S. Karger AG
数据来源: Karger
摘要:
The chromosome complement of metaphase II oocytes matured by different methods was determined. These oocytes were collected from young and old Swiss-Webster random bred and CBA inbred mice. The results from the two strains were remarkably similar. Superovulation caused no increase in aneuploidy frequencies; however, in vitro maturation resulted in increased hyperploidy rates for oocytes from younger females of both strains. Of the six possible comparisons regarding a maternal age effect, there were no significant increases in hyperploidy. The absence of a maternal age effect on the first meiotic division of oocytes, while such an effect does exist for mid-gestation mouse fetuses, suggests that the maternal age effect on aneuploidy may be due to a decreased ability to select against (abort) aneuploid embryos/fetuses as a function of increasing maternal age.
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