AMIDOHYDROLASES OF BRAIN;1ENZYMATIC HYDROLYSIS OFN‐ACETYL‐l‐ASPARTATE AND OTHERN‐ACYL‐l‐AMINO ACIDS
作者:
F. B. Goldstein,
期刊:
Journal of Neurochemistry
(WILEY Available online 1976)
卷期:
Volume 26,
issue 1
页码: 45-49
ISSN:0022-3042
年代: 1976
DOI:10.1111/j.1471-4159.1976.tb04434.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract–Mammalian brain contains 2N‐acylamino acid amidohydrolases resembling the respective kidney enzymes. The anatomical and subcellular distribution of the enzymes; the substrate specificities and interspecies activities of the partially purified amidohydrolases have been studied. A considerable proportion of the amidohydrolase activity of subcellular fractions was found to be associated with the paniculate matter. The increased activities of the particulate enzymes in the presence of Triton X‐100 and chloroacetyl amino acid substrates suggest that significant amounts of the enzymes are in the bound or latent
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