Determination of Phenytoin, Phenobarbitone, and Methyl Phenobarbitone in Combination
作者:
M.G. El-Bardicy,
M.F. El Tanas,
E.S. El-Zanfally,
期刊:
Spectroscopy Letters
(Taylor Available online 1997)
卷期:
Volume 30,
issue 2
页码: 267-287
ISSN:0038-7010
年代: 1997
DOI:10.1080/00387019708006987
出版商: Taylor & Francis Group
关键词: Phenytoin;Phenobarbitone;Methylphenobarbitone;Densitometry;1H-NMR;Spectrophotometry
数据来源: Taylor
摘要:
This work is concerned with the determination of a mixture of phenytoin, phenobarbitone and methylphenobarbitone by two different techniques. The first one depends on the simultaneous quantitative densitometric evaluation of thin layer chromatograms of the three drugs. The second is the application of quantitative1H-NMR spectrometry for the simultaneous determination of phenobarbitone and methylphenobarbitone in the presence of phenytoin, while phenytoin was determined in this mixture by modifying the benzophenone spectrophotometric procedures.(1—4)
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