Eosinophil granulocytopoiesis in hepatic periovular granulomas during the chronic phase of experimental murineSchistosomiasis mansoni
作者:
Maurice Geuskens,
Radovan Borojevic,
Paulette Gansen,
期刊:
Biology of the Cell
(WILEY Available online 1991)
卷期:
Volume 71,
issue 1‐2
页码: 89-96
ISSN:0248-4900
年代: 1991
DOI:10.1016/0248-4900(91)90055-R
出版商: Blackwell Publishing Ltd
关键词: Schistosomiasis mansoni;granulomas;eosinophils;mouse;electron microscopy
数据来源: WILEY
摘要:
Summary—We have observed in hepatic periovular granulomas of C3H mice infected withSchistosoma mansoni, in the chronic phase of the disease (12–19 weeks of infection), groups of early precursors and immature eosinophil granulocytes corresponding, at the ultrastructural level, to promyelocytes and myelocytes. Mitosis also seen in eosinophil myelocytes. These eosinophil myeloid foci were observed in close contact with macrophages and epithelioid cells, and they were surrounded by an extracellular matrix, rich in collagen fibres. These morphological observations give support to the concept of a peripheral proliferation of cosinophils in chronic schistosomiasis, mediated by a factor secreted by macrophages present in granulo
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