Sequential DNA Flow Cytometry in Metastatic Malignant Melanoma
作者:
Detlef Bartkowiak,
Friedrich Otto,
Johannes Schumann,
Andrea Lippold,
Hubert Drepper,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 2
页码: 154-157
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226916
出版商: S. Karger AG
关键词: Melanoma;Metastasis;Flow cytometry;Ploidy;Heterogeneity
数据来源: Karger
摘要:
Sequential flow cytometry was performed on 73 metastatic malignant melanomas, derived from 804 primary tumors. Tumor thickness was confirmed an excellent prognostic parameter in primary melanoma, but did not allow reliable predictions in metastatic disease. Also, aneuploidy and genetic heterogeneity, both common in metastatic melanoma, were equally distributed among patients differing in survival time. However, a remarkable acceleration was observed in the generation of abnormal cell lines in patients dying early of metastatic disease.
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