首页   按字顺浏览 期刊浏览 卷期浏览 Repeat sizes at CAG/CTG lociCTG18.1, ERDA1andTGC13‐7ain schizophrenia
Repeat sizes at CAG/CTG lociCTG18.1, ERDA1andTGC13‐7ain schizophrenia

 

作者: T. Bowen,   C. Guy,   A. Cardno,   J. Vincent,   J. Kennedy,   L. Jones,   M. Gray,   R. Sanders,   G. McCarthy,   K. Murphy,   M. Owen,   M. O'Donovan,  

 

期刊: Psychiatric Genetics  (OVID Available online 2000)
卷期: Volume 10, issue 1  

页码: 33-37

 

ISSN:0955-8829

 

年代: 2000

 

出版商: OVID

 

关键词: schizophrenia;trinucleotide repeats;CTG18.1, ERDA 1, TGC13‐7a

 

数据来源: OVID

 

摘要:

&NA;A number of studies using the repeat expansion detection (RED) technique have suggested an association between unknown large CAG/CTG repeats and schizophrenia. The polymorphic CAG/CTG repeat lociCTG18.1andERDA1have been reported to account for a high proportion (∼ 90%) of the large repeats detected by RED and may therefore be responsible for the cited association. The recently described locusTGC13‐7acontains a highly polymorphic CTA/TAG and CAG/CTG composite repeat, and is thus another authentic candidate. In the present investigation, each locus was analysed for association with schizophrenia in a sample of 206 patients and 219 group‐matched controls. No evidence for association ofCTG18.1, ERDA1and/orTGC13‐7awith schizophrenia was found. The combined data accounted for only 54% of the CAG/CTG arrays of > 40 repeats found in our previous RED analysis.

 

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