Repeat sizes at CAG/CTG lociCTG18.1, ERDA1andTGC13‐7ain schizophrenia
作者:
T. Bowen,
C. Guy,
A. Cardno,
J. Vincent,
J. Kennedy,
L. Jones,
M. Gray,
R. Sanders,
G. McCarthy,
K. Murphy,
M. Owen,
M. O'Donovan,
期刊:
Psychiatric Genetics
(OVID Available online 2000)
卷期:
Volume 10,
issue 1
页码: 33-37
ISSN:0955-8829
年代: 2000
出版商: OVID
关键词: schizophrenia;trinucleotide repeats;CTG18.1, ERDA 1, TGC13‐7a
数据来源: OVID
摘要:
&NA;A number of studies using the repeat expansion detection (RED) technique have suggested an association between unknown large CAG/CTG repeats and schizophrenia. The polymorphic CAG/CTG repeat lociCTG18.1andERDA1have been reported to account for a high proportion (∼ 90%) of the large repeats detected by RED and may therefore be responsible for the cited association. The recently described locusTGC13‐7acontains a highly polymorphic CTA/TAG and CAG/CTG composite repeat, and is thus another authentic candidate. In the present investigation, each locus was analysed for association with schizophrenia in a sample of 206 patients and 219 group‐matched controls. No evidence for association ofCTG18.1, ERDA1and/orTGC13‐7awith schizophrenia was found. The combined data accounted for only 54% of the CAG/CTG arrays of > 40 repeats found in our previous RED analysis.
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