MISOPROSTOL FOR CERVICAL RIPENING AND LABOR INDUCTIONA META‐ANALYSIS
作者:
Luis Sanchez-Ramos,
Andrew Kaunitz,
Robert Wears,
Isaac Delke,
Francisco Gaudier,
期刊:
Obstetrics & Gynecology
(OVID Available online 1997)
卷期:
Volume 89,
issue 4
页码: 633-642
ISSN:0029-7844
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
ObjectiveTo analyze published randomized trials assessing the safety and efficacy of misoprostol for cervical ripening and labor induction.Data SourcesWe supplemented a search of entries in electronic data bases with references cited in original studies and review articles to identify randomized trials of misoprostol for cervical ripening and labor induction.Methods of Study SelectionTwo blinded investigators performed independent trial quality evaluation and data abstraction of randomized clinical trials assessing the efficacy of misoprostol as a cervical ripening and labor-inducing agent.Tabulation, Integration, and ResultsWe calculated an estimate of the odds ratio (OR) and risk difference for dichotomous outcomes, using both a random- and fixedeffects model. Continuous outcomes were pooled using a variance-weighted average of the within-study difference in means. Of 16 studies identified, eight met our criteria for meta-analysis. These eight trials included 966 patients (488 received misoprostol and 478 were controls). Women who received misoprostol for cervical ripening and labor induction had a significantly lower overall cesarean rate (OR 0.67, 95% confidence interval [CI] 0.48, 0.93) and a higher incidence of vaginal delivery within 24 hours of misoprostol application (OR 2.64, 95% CI 1.87, 3.71). Use of misoprostol was associated with a higher incidence of tachysystole (OR 2.70, 95% CI 1.80, 4.04) but not hyperstimulation (OR 1.91, 95% CI 0.98, 3.73). The incidences of abnormal 5-minute Apgar scores and admissions to the neonatal intensive care unit were similar in the misoprostol and control groups. The pooled estimate of the mean interval from start of induction to delivery was 4.6 hours fewer (95% CI −3.5, −5.7) in the misoprostol group.ConclusionsPublished data confirm the safety and efficacy of intravaginal misoprostol as an agent for cervical ripening and labor induction.
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