Role of Thrombin in CNS Damage Associated with Intracerebral HaemorrhageOpportunity for Pharmacological Intervention?
作者:
Hideki Matsuoka,
Rikuzo Hamada,
期刊:
CNS Drugs
(ADIS Available online 2002)
卷期:
Volume 16,
issue 8
页码: 509-516
ISSN:1172-7047
年代: 2002
出版商: ADIS
关键词: Argatroban, pharmacodynamics;Cerebral haemorrhage;Thrombin inhibitors, pharmacodynamics
数据来源: ADIS
摘要:
Intracerebral haemorrhage (ICH) results in high mortality and morbidity. The most important causes of neurological deterioration after ICH are progression of oedema and injury to nerve cells and axons surrounding the haematoma, as well as haematoma enlargement. Recent studies have indicated that thrombin, formed upon clotting of the haematoma, plays an important role in these processes. As opposed to conventional therapeutic approaches, administration of a thrombin inhibitor could effectively limit oedema formation and neuronal damage, improving survival and functional outcome. A small, preliminary clinical trial has suggested that antithrombin therapy with intravenously administered argatroban may be useful in treatment of ICH. Randomised, controlled studies are needed to confirm these initial findings.
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