Prolactin Release Induced by Opiate Agonists, Effect of Glucocorticoid Pretreatment in Intact and Adrenalectomized Rats
作者:
Thanh Kiem,
Béla Kanyicska,
Ervin Stark,
Mårton I.K. Fekete,
期刊:
Neuroendocrinology
(Karger Available online 1988)
卷期:
Volume 48,
issue 2
页码: 174-179
ISSN:0028-3835
年代: 1988
DOI:10.1159/000125006
出版商: S. Karger AG
关键词: Opioid peptides;Opiate agonists;Prolactin;Glucocorticoids;Opiate receptors
数据来源: Karger
摘要:
Cortisol administered at a dose of 25 mg/kg 24 h before measurements decreased the prolactin secretion induced by intraventricularly given opioids (dynorphin, beta-endorphin, Met-enkephalin or D-Met-Pro-enkephalin-amide). The effect of cortisol was depressed by actinomycin D pretreatment. The cortisol-induced inhibition of the action of morphine was facilitated in adrenalectomized animals; measuring the effects of increasing doses of cortisol a maximal inhibition was obtained at a dose of 5 mg/kg. The opioid-induced corticosterone secretion was not affected 24 h after a single administration of cortisol. The present results show that the cortisol-induced inhibition of opioid-induced prolactin secretion is dependent on protein synthesis and independent of changes in drug metabolism, and of the type of opiate receptor preferentially affected by the opiate agonists employed.
点击下载:
PDF
(840KB)
返 回