Effect of the Activation of the Kinin-Forming System on the Potency of Chlorpromazine
作者:
J. Moniuszko-Jakoniuk,
K. Wiśniewski,
A. Bodzenta,
期刊:
Pharmacology
(Karger Available online 1974)
卷期:
Volume 12,
issue 4-5
页码: 216-223
ISSN:0031-7012
年代: 1974
DOI:10.1159/000136542
出版商: S. Karger AG
关键词: Activation;Chlorpromazin;CNS;Kallikrein;Kinins
数据来源: Karger
摘要:
Studies were performed on the effects of the activation of the kinin-forming system on the action of chlorpromazine in rats and mice. It was found that in animals with CNS kinin enzymes previously activated with kallikrein, or in animals which had been given bradykinin, the psychodepressive activity of chlorpromazine became markedly higher. The administration of Trasylol® brought about a decrease of the postkallikrein activation of kinin-generating enzymes and abolished the potentiating kallikrein effect on the action of chlorpromazine. Under multiple pathological conditions which are followed by increased kinin levels, an altered potency of drugs acting on CNS should be taken into consideration
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