Spectrophotometric Determination of Cefadroxil in Drug Formulations using flow Injection Analysis
作者:
I.F. Al-Momani,
I. Awni,
H.S. Khalil,
F. Esmadi,
期刊:
Analytical Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 15
页码: 2977-2988
ISSN:0003-2719
年代: 1999
DOI:10.1080/00032719908543021
出版商: Taylor & Francis Group
关键词: Cefadroxil;Spectrophotometric;Flow Injection Analysis;Pharmaceutical Analysis
数据来源: Taylor
摘要:
A flow injection analysis method for the determination of cefadroxil is proposed. The method is based on the hydrolysis of cefadroxil in sodium hydroxide solution followed by treatment with 1,4-phenylenediamine and Fe(III) in sulphuric acid solution to produce a violet color which has a maximum absorption at 600 nm. Variables such as acidity, reagent concentrations, flow rate of reagents and other FI parameters were optimized to produce the most sensitive and reproducible results. The calibration graph is linear between 80 - 320 mg/l. The detection limit is 40 mg/l with a relative standard deviation, RSD (n=6) of 1.8%. The proposed method, combining the advantages of speed and accuracy was applied to the determination of cefadroxil in pharmaceutical preparations. The results have been compared with those obtained using HPLC method (USP-procedure). Excellent agreement between the results of the proposed method and the HPLC method was observed.
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