首页   按字顺浏览 期刊浏览 卷期浏览 Oral dosage regimen in the nonlinear pharmacokinetics of sulphadimethoxine in pigs
Oral dosage regimen in the nonlinear pharmacokinetics of sulphadimethoxine in pigs

 

作者: M. Shimoda,   E. Kokue,   R. Suzuki,   T. Hayama,   T. B. Vree,  

 

期刊: Veterinary Quarterly  (Taylor Available online 1990)
卷期: Volume 12, issue 1  

页码: 7-13

 

ISSN:0165-2176

 

年代: 1990

 

DOI:10.1080/01652176.1990.9694235

 

出版商: Taylor & Francis Group

 

数据来源: Taylor

 

摘要:

An oral high dosage regimen of sulphadimethoxine (SDM) was examined in pigs. The dose (50 mg/kg) in the therapeutic range, showed nonlinear pharmacokinetics, and administered by drench once a day for 4 days. The unbound plasma concentration‐time profile was compared with that of the dosage regimen based on nonlinear pharmacokinetics, where a pharmacokinetic model and parameters were used except for the first order absorption rate constant (ka) and bioavailability (F). F and ka were obtained from oral and intravenous administration of 20 and 10 mg/kg of SDM. The unbound plasma concentration was observed almost within the setting range by the dosage regimen through the experimental period. This result suggested that the dosage regimen, based on the nonlinear pharmacokinetic model, resulted in an appropriate effect in the clinical use.

 

点击下载:  PDF (1205KB)



返 回