Inhibitory Effects of the New Bombesin Receptor Antagonist RC-3095 on the Luteinizing Hormone Release in Rats
作者:
Jacek Pinski,
Tetsu Yano,
Andrew V. Schally,
期刊:
Neuroendocrinology
(Karger Available online 1992)
卷期:
Volume 56,
issue 6
页码: 831-837
ISSN:0028-3835
年代: 1992
DOI:10.1159/000126313
出版商: S. Karger AG
关键词: Bombesin receptor antagonist;Luteinizing hormone;Follicle-stimulating hormone
数据来源: Karger
摘要:
The effects of bombesin receptor antagonist RC-3095 and gastrin-releasing peptide [GRP (14–27)] on basal luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone levels, as well as on the release of LH and FSH in response to LH-releasing hormone, were studied in normal and castrated male rats. We also examined the release of LH and FSH after intracerebroventricular injection of RC-3095 under different types of anesthesia (urethane, sodium pentobarbital, Metofane). Following injection of 10 µg RC-3095 into the lateral brain ventricle, serum LH levels were rapidly and significantly (p < 0.001) lowered. This effect lasted for at least 60 min and was not affected by the type of anesthetic used. Serum FSH levels were not affected by intracerebroventricular administration of RC-3095 or GRP (14–27), indicating different central control mechanisms between LH and FSH release. The suppressive effect of RC-3095 on LH release could be completely prevented by prior intracerebroventricular administration of GRP (14–27) at a dose of 1 µg, but intravenous administration of either peptide RC-3095 or GRP (14–27) did not change the basal levels of LH, FSH, and testosterone. The pituitary LH response to LH-releasing hormone was also not modified by intravenous administration of RC-3095. These results indicate that bombesin-like peptides might be involved in control of LH release from the pituitary by an action on the CNS which is mediated by specific bombesin
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