Central nervous system action of melatonin on gastric acid and pepsin secretion in pylorusligated rats
作者:
Kimitoshi Kato,
Ichiro Murai,
Satoshi Asai,
Yasuo Takahashi,
Yoshiaki Matsuno,
Sachiko Komuro,
Hanzo Kurosaka,
Ariyoshi Iwasaki,
Koichi Ishikawa,
Yasuyuki Arakawa,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 11
页码: 2447-2450
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Gastric acid;Intracisternal injection;Melatonin;Pepsin
数据来源: OVID
摘要:
WE recently demonstrated that centrally administered melatonin at low doses inhibits the induction of gastric lesions by water-immersion restraint stress. To investigate the mechanism of the potent anti-ulcer action of melatonin, the central nervous system (CNS) effects of melatonin on gastric acid and pepsin secretion were studied in conscious pylorus-ligated rats. Intracisternal(i.c.) melatonin (1–100 ng) dose-dependently decreased acid and pepsin output, while a higher i.p. dose (1 μg) had no inhibitory effect. The i.c. melatonin did not change serum gastrin concentrations. Serum melatonin concentrations at 1 and 4 h after i.c. administration of 10–100 ng melatonin did not differ from those in rats receiving i.c. vehicle. The present results suggest that melatonin administered centrally modulates the secretion of gastric acid and pepsin which may explain, at least in part, the protective, anti-stress role of melatonin in the gastric mucosa observed in our previous study.
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