Selective Impairment of Taurine Transport by Cyclosporin A in a Human Placental Cell Line
作者:
SAMMANDA,
RAMAMOORTHY FREDERICK,
LEIBACH VIRENDRA,
MAHESH VADIVEL,
期刊:
Pediatric Research
(OVID Available online 1992)
卷期:
Volume 32,
issue 1
页码: 125-127
ISSN:0031-3998
年代: 1992
出版商: OVID
数据来源: OVID
摘要:
We investigated, using a human placental choriocarcinoma cell line as a model, the effects of the immunosuppressive drug cyclosporin A on several placental transport systems mediating the transfer of glucose and amino acids from mother to fetus. The results of the investigation show that the transport system responsible for the transfer of taarine is selectively impaired by the drug, whereas the other transport systems are either stimulated or not affected. The inhibitory effect of the drug on taurine transport appears to be due to interference with calmodulin-dependent processes because calmodulin antagonists such as W-7, calmidazolium, and CGS 9343B mimic the effects of cyclosporin A. FK506, another immunosuppressive drug that is currently undergoing clinical trials, does not have this inhibitory effect.
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