Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751)
作者:
Susan Grant,
Sai Shankar,
Ruth Chalmers-Redman,
William Tatton,
Moshe Szyf,
A Cuello,
期刊:
NeuroReport
(OVID Available online 1999)
卷期:
Volume 10,
issue 1
页码: 41-46
ISSN:0959-4965
年代: 1999
出版商: OVID
关键词: Amyloid precursor protein;Electron microscopy;Embryonal carcinoma;Membrane potential;Mitochondria
数据来源: OVID
摘要:
METABOLIC hypofunction is a common finding in a number of neurodegenerative diseases, including Alzheimer's disease (AD). The strong linkage between the amyloid precursor protein (APP) and AD led us to examine whether over-expression of this protein in CNS-type cells had an effect on mitochondria. We found abnormal morphology in mitochondria of the neuroectodermal progeny of P19 cells stably transfected with human APP751. In addition, the mitochondria of APP-transfected clones had a decreased mitochondrial membrane potential. These changes were independent of Aβ toxicity and distinct from complex I inhibition. Our results have important implications for the earliest events in the pathophysiology of AD and, by extrapolation, for intervention therapies.
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