Neuroprotective activity of acetyl‐L‐carnitine: Studies in vitro
作者:
G. Forloni,
N. Angeretti,
S. Smiroldo,
期刊:
Journal of Neuroscience Research
(WILEY Available online 1994)
卷期:
Volume 37,
issue 1
页码: 92-96
ISSN:0360-4012
年代: 1994
DOI:10.1002/jnr.490370112
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: glutamate neurotoxicity;β amyloid;Alzheimer's disease;energy metabolism
数据来源: WILEY
摘要:
AbstractThe neuroprotective properties of acetyl‐L‐carnitine (ALCAR) were investigated in primary cell cultures from rat hippocampal formation and cerebral cortex of 17‐day‐old rat embryos. Chronic exposure to ALCAR (10–50 μM), reduced the cell mortality induced by 24 hr fetal calf serum deprivation. Protection was partial when the neuronal cells, chronically treated with ALCAR (50 μM,) were exposed to glutamate (0.25‐1 mM)and kainic acid (250–500 μM) for 24 hr. The neurotoxity induced by N‐methyl‐D‐aspartate (NMDA, 250 μm) was attenuated by the acute co‐exposure with ALCAR (1mM), the chronic treatment with ALCAR (50 μM)significantly reduced the neuronal death induced by NMDA (0.25–1mM) Cell mortality was also investigated in ALCAR‐treated hippocampal cultures chronically treated with β‐amyloid fragment 25–35. ALCAR appeared to have neuroprotective activity. This suggests an explanation of the positive results obtained with ALCAR in the treatment of alzheime
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